A rare opportunity to own a piece of Fort Smith history in one of the city's most desirable downtown-adjacent locations. Just minutes from the Downtown Entertainment District, this remarkable two-story home blends timeless craftsmanship, architectural character, and exceptional flexibility. Step inside to discover rich original woodwork, hardwood floors, decorative fireplaces, French doors, soaring ceilings, and a stunning grand staircase that serves as the heart of the home. Generous living and dining spaces, oversized bedrooms, and multiple gathering areas offer room to live, work, and entertain with ease. The distinctive turret-style room, surrounded by windows, creates the perfect setting for a home office, studio, reading room, or creative retreat. Beyond its residential appeal, the property is also zoned Neighborhood Commercial, creating unique live-work possibilities. A private side entrance and rear access staircase provide separation from the main living areas, making the property ideal for a professional office, consulting practice, studio, or personal service business, subject to buyer verification of permitted uses. The location is equally impressive. Enjoy convenient access to the vibrant Downtown Entertainment District, known for its dining, shopping, nightlife, and community events. You're also just moments from the acclaimed Fort Smith Regional Art Museum, a cultural centerpiece of downtown Fort Smith, along with nearby attractions such as Fort Smith National Historic Site and Fort Smith Trolley Museum. Local favorites including Prima Italia, AJ's Oyster House, and The Back Porch are all just minutes away, making it easy to enjoy the best of Fort Smith's food and entertainment scene. From the clawfoot tub to the intricate millwork and historic details throughout, 109 N. 16th Street offers a rare blend of character, versatility, and location—perfect for those seeking a distinctive home, a live-work opportunity, or both.